What Is “Ozempic Vulva”? All You Need to Know About the Side Effects of GLP-1
Introduction
GLP-1 medications like Ozempic, Wegovy, and Zepbound have become widely known for their effectiveness in promoting weight loss. However, alongside common side effects such as nausea and stomach discomfort, some women have reported unexpected changes in their vaginal health, which has been popularly referred to online as “Ozempic vulva.”
What Is “Ozempic Vulva”?
“Ozempic vulva” isn’t an official medical diagnosis but a term used to describe symptoms including sagging skin around the vulva, vaginal dryness, and weakened pelvic muscles. Some women have also noticed increased vaginal discharge or discomfort, particularly during activities like biking or prolonged sitting.
These changes are believed to stem not from the medication directly acting on genital tissues but rather as a consequence of rapid and significant weight loss. GLP-1 medications do not directly affect the vulva or pelvic floor muscles. However, the rapid reduction of body fat and the skin’s limited ability to adjust quickly can lead to visible changes—especially in areas like the vulva that naturally contain fatty tissue.
Since weight loss impacts each person differently, some individuals may notice more pronounced changes in regions with softer tissue, as fat volume decreases and skin laxity becomes more noticeable. When fat pads that normally provide volume and support to areas like the mons pubis and labia majora diminish quickly, it can cause the skin and surrounding tissues to appear looser or saggy.
Additional Symptoms: Vaginal Dryness and Muscle Weakness
Along with sagging skin, some women experience vaginal dryness and pelvic muscle weakness. However, experts clarify that these symptoms are typically linked to hormonal factors such as menopause or contraceptive use, rather than the GLP-1 drugs themselves.
Muscle weakness, including in the pelvic floor, may also arise if rapid weight loss leads to loss of lean muscle mass without adequate nutrition or strength training.
When Should You Seek Medical Advice?
While changes in appearance alone might not be a cause for concern, it’s important to monitor for symptoms like urinary leakage, pelvic heaviness, bulging, or painful vaginal dryness. These could indicate pelvic floor dysfunction or hormonal imbalances that require medical attention.
If vaginal irritation or discomfort arises during treatment with GLP-1 medications, it is advisable to consult your healthcare provider promptly.
Managing and Treating Symptoms
Treatment for these symptoms usually starts with conservative approaches:
- Pelvic floor physical therapy and exercises such as Kegels can help strengthen muscles and improve support.
- Vaginal moisturisers and lubricants are effective for relieving dryness.
- Topical estrogen may be prescribed for postmenopausal women experiencing significant dryness or atrophy.
Surgical interventions are generally reserved for severe or persistent cases.
Additionally, experts recommend adopting a gradual, well-paced weight loss plan and incorporating resistance training to help preserve muscle tone and skin elasticity.
Broader Context: Not Unique to GLP-1 Drugs
It’s important to note that these types of changes can occur with any rapid, significant weight loss — whether from bariatric surgery, dieting, or medication. The speed and extent of weight loss influence how noticeable these changes are, with slower weight loss allowing the body more time to adjust.
Conclusion
“Ozempic vulva” highlights how rapid weight loss can affect not just overall health but also sensitive areas of the body. Understanding the root causes and available treatment options can empower women to manage these side effects effectively while pursuing their weight loss goals. Always discuss any new symptoms with your healthcare provider to ensure the best care and guidance.
- Medicine and Diseases
- 24 September 2025
- 11:00
Reviewed by Dr Aarti Nehra (MBBS, MMST)
